Most single amino acid substitutions (SAASs) lack experimental annotation of their functional impact. SNPdbe is a database and a webinterface that is designed to fill the annotation gap left by the high cost of experimental testing for functional significance of protein variants. It joins related bits of knowledge, currently distributed throughout various databases, into a consistent, easily accessible, and updatable resource. We currently cover over 155,000 protein sequences which come from more than 2,600 organisms. Overall we reference more than one million SAASs consisting of natural variants, SAASs from mutagenesis experiments and sequencing conflicts.

For more details, please refer to our statistics overview.

2012-03-05:Updated to human dbSNP release b135.
2012-02-21:Result file now contains dbSNP and SwissVar ids.
2012-02-20:Updated to recent Swiss-Prot release (2012-01).
2012-02-13:SNPedia references our service.
2012-02-09:Search results are now accessible through a direct link.
2012-08-13:Several website bugs fixed.

SNPdbe offers the following pieces of information (if available) on each SAAS:

  • Experimentally derived functional and structural impact
  • Predicted functional effect
  • Associated disease
  • Average heterozygosity
  • Experimental evidence of the nsSNP
  • Evolutionary conservation of wildtype and mutant amino acid
  • Link-outs to external databases

We offer a convenient webinterface to query SAASs on the following levels:

  • Protein and gene identifiers and keywords
  • Disease keywords
  • Protein sequence on different sequence identity thresholds
  • Variant identifier (dbSNP rs, SwissVar, PMD) or specific mutant like XposY and specified sequence

Terms of Use

  • This Database may be used by the general public.
  • Without derogating from the generality of the above, the Database may not be used to provide services or products to any third parties or to sell, rent, lease, loan, distribute or otherwise transfer all or any portion of the Database to a third party.
  • Academic End User is hereby defined as:
    1. An individual scientist who will not use the Database within the framework of his/her work for or with commercial organizations of any kind
    2. A university or other non-profit research organization that will not use the Dataabse for performing research sponsored by commercial organizations of any kind.
  • By downloading this Database, you certify that you are an Academic End User and that you will use the downloaded Database solely for non-commercial research purposes.
  • Non-Academic End Users wishing to download the database should contact Biosof LLC at info@bio-sof.com for commercial use of the Database.